vs 

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"Of course" is a form of "of course", a phrase which is often translated as "por supuesto". "Be familiar with" is a transitive verb phrase which is often translated as "estar familiarizado con". Learn more about the difference between "be familiar with" and "of course" below.
be familiar with(
bi
 
fuh
-
mihl
-
yuhr
 
wihth
)
A transitive verb phrase is a phrase that combines a verb with a preposition or other particle and requires a direct object (e.g., take out the trash.).
transitive verb phrase
a. estar familiarizado con
Are you familiar with video calls? I want to make one and I don't know how.¿Estás familiarizado con las videollamadas? Quiero hacer una y no sé.
b. familiarizarse con
Here's a list of terms you should be familiar with to succeed in the exam.Esta es una lista de los términos con los que deberías familiarizarte para tener éxito en el examen.
c. conocer
George shouldn't do that and he knows it. He is familiar with the regulations.George no debería hacer eso y lo sabe. Conoce el reglamento.
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of course(
uhv
 
kors
)
A phrase is a group of words commonly used together (e.g., once upon a time).
phrase
a. por supuesto
Are you coming with us? - Of course!¿Vienen con nosotros? - ¡Por supuesto!
b. claro
Could you help me with this? - Of course!¿Me podría ayudar con esto? - ¡Claro!
c. desde luego
Of course you are right, as always.Desde luego que tienes razón, como siempre.
d. cómo no
Are we invited? - Of course!¿Estamos invitados? - ¿Cómo no?
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